Young-Jung Lee Selected Research

4-O-methylhonokiol

5/2014	Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol.
2/2012	Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models.
1/2012	4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity.
1/2011	4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease.

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Young-Jung Lee Research Topics

Disease

8	Alzheimer Disease (Alzheimer's Disease) 01/2013 - 01/2011
7	Neuroinflammatory Diseases 07/2021 - 10/2011
3	Cognitive Dysfunction 05/2014 - 07/2012
3	Inflammation (Inflammations) 01/2013 - 10/2010
2	Dementia (Dementias) 12/2012 - 01/2012
1	Amyloid Plaque 07/2021
1	Amnesia (Dissociative Amnesia) 07/2012
1	Memory Disorders (Memory Loss) 01/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2012
1	Arthritis (Polyarthritis) 10/2011
1	Neoplasms (Cancer) 05/2011
1	Viremia 01/2011
1	Persistent Infection 01/2011
1	Chronic Hepatitis C 01/2011
1	Liver Cirrhosis (Hepatic Cirrhosis) 09/2010
1	Fibrosis (Cirrhosis) 09/2010
1	Hepatitis C 09/2007
1	Communicable Diseases (Infectious Diseases) 09/2007
1	Virus Diseases (Viral Diseases) 04/2007

Drug/Important Bio-Agent (IBA)

5	Amyloid (Amyloid Fibrils)IBA 07/2021 - 01/2011
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2021 - 01/2012
4	4-O-methylhonokiolIBA 05/2014 - 01/2011
3	Ethanol (Ethyl Alcohol)IBA 03/2013 - 05/2012
3	LipopolysaccharidesIBA 01/2013 - 01/2012
2	Proteins (Proteins, Gene)FDA Link 07/2021 - 02/2012
2	Messenger RNA (mRNA)IBA 07/2021 - 09/2010
2	2,4-bis(p-hydroxyphenyl)-2-butenalIBA 01/2013 - 10/2011
2	Amyloid beta-PeptidesIBA 01/2013 - 12/2012
2	CytokinesIBA 01/2013 - 10/2010
2	AntioxidantsIBA 02/2012 - 05/2011
1	Interleukin-6 (Interleukin 6)IBA 07/2021
1	Macrophage Colony-Stimulating FactorIBA 07/2021
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 07/2021
1	Interleukin-2 (IL2)IBA 07/2021
1	Dopamine (Intropin)FDA LinkGeneric 04/2016
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 04/2016
1	Phenazopyridine (Pyridium)FDA LinkGeneric 04/2016
1	Estrogens (Estrogen)FDA Link 04/2016
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2013
1	obovatolIBA 07/2012
1	Scopolamine (Hyoscine)FDA Link 07/2012
1	Neuroprotective AgentsIBA 05/2012
1	NF-kappa B (NF-kB)IBA 02/2012
1	PolyphenolsIBA 02/2012
1	thiacremononeIBA 01/2012
1	Drinking WaterIBA 01/2012
1	FructoseIBA 10/2011
1	DNA (Deoxyribonucleic Acid)IBA 10/2011
1	Transcription Factors (Transcription Factor)IBA 10/2011
1	Tyrosine (L-Tyrosine)FDA Link 10/2011
1	Advanced Glycation End ProductsIBA 10/2011
1	Antiviral Agents (Antivirals)IBA 01/2011
1	AntibodiesIBA 01/2011
1	Alanine Transaminase (SGPT)IBA 01/2011
1	EnzymesIBA 01/2011
1	ChemokinesIBA 10/2010
1	Dimethylnitrosamine (Nitrosodimethylamine)IBA 09/2010
1	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2010
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2010
1	1-O-hexyl-2,3,5-trimethylhydroquinoneIBA 09/2010
1	Small Interfering RNA (siRNA)IBA 09/2007
1	RNA (Ribonucleic Acid)IBA 04/2007

Therapy/Procedure

2	Intraperitoneal Injections 01/2012 - 09/2010
1	Therapeutics 09/2007
1	RNAi Therapeutics 09/2007